#AskJcal Request | Got a burning question for JCal? We want to hear it, and he might answer it on an upcoming episode of TWiST. Send us an audio or video clip of you asking the question. You can hit us up via DM or email your file to nils@launch.co. And be sure to include your name and a social media link so we can shout you out! (A little plug for your company is okay, too, but let’s not go nuts.) |
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| Top Stories | OpenAI said an internal model more capable than GPT-6 Astra used 10,000 agents over 88 hours to produce a proposed solution to the Navier-Stokes Millennium Prize Problem. — CNBC Suno replaced its models with Suno v6, trained on licensed music from Warner Music Group, BMG, and Believe. — TechCrunch Meta launched Muse, a personal AI agent that runs in its own cloud VM with a built-in browser. — Axios Apple's "Surprise and Shine" event kicks off at 1 PM ET, where the company is expected to headline its first foldable, the iPhone Duo. — MacRumors
| Top Funding Announcements | Savvy Wealth — the RIA software platform for independent financial advisors raised a $100M Series C led by Halo Fund, pushing total funding past $200M. — Business Wire Harvey — the legal AI startup closed a $550M round at a $15.6B valuation, up from the $15.5B target it was reportedly chasing a month earlier. — Bloomberg Royal Group — Sheikh Tahnoon bin Zayed's investment arm is backing Orbitworks' $1B Altair satellite constellation, a 50-satellite Earth-observation network. — Bloomberg Cognition — the AI coding startup closed a $2B Series E at a $48B valuation, up from $26B in May. — TechCrunch Bluecore Energy — the startup building barge-mounted small nuclear reactors for ports raised an oversubscribed $50M seed led by Silverton Partners. — TechCrunch
| A Message from The Conservation Fund: | Find out more about how The Conservation Fund is protecting land, wildlife, and our shared access to the great outdoors while also providing economic opportunities. Visit https://conservationfund.org. | |
| | This Week in Startups |  | Dr. Mark Hyman on Function Health & GLP-1 microdosing | E2334 |
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| Timestamps: 0:00 What is a function, actually 6:01 Healthspan vs. sick care 9:34 Odoo - The all-in-one business platform. Your first app is free! Get started today at https://Odoo.com/twist 10:50 A $300 vitamin D test vs. a $10 one 17:26 Should a 25-year-old get a whole-body MRI? 20:00 Northwest Registered Agent - Got a new business idea? Northwest Registered Agent helps you bring it to life. Get a free domain, email, phone number, and more - with no purchase required! Learn more at www.northwestregisteredagent.com/twistdomain 23:41 Why is medicine still running on paper 24:59 The study where the chatbot beat the doctors 26:20 micro1, doctors in the loop, and why AI still needs guardrails 28:08 Wearables, records, and the CD-ROM problem 29:25 Rippling - Thanks to our partners at Rippling! Head to https://Rippling.ai/twist and get the only AI built to give you full visibility across your startup and take complex actions across your entire business. 32:09 The wearable that caught Jason's COVID 33:49 Alcohol, sugar, and why almost nobody tests your insulin 39:18 GLP-1s: Jason's 213-to-168 story 41:40 Microdosing GLP-1s, muscle loss, and "skinny fat" 48:06 Overdiagnosing mental illness: SSRIs, Adderall, and a lost decade 49:35 The biology underneath depression and anxiety 53:50 Psychedelics: ketamine, ibogaine, and the second revolution in psychiatry |
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| TWiST Partner Offers | Northwest Registered Agent: Got a new business idea? Northwest Registered Agent helps you bring it to life. Get a free domain, email, phone number, and more - with no purchase required! — Learn more at www.northwestregisteredagent.com/twistdomain NetSuite: For the first time ever, you can try NetSuite Next for free. If your revenues are at least in the seven figures, go to netsuite.ai/twist. Vanta: Get $1000 off your SOC 2 at https://www.vanta.com/twist
| Today’s Fascinating Fact from Harmonic | Bluecore Energy builds small modular water-cooled nuclear reactors that operate on floating barges, where they can provide power to ports, data centers, and other heavy infrastructure. They’ve brought in considerable seed funding for the project, ~$79 million following today’s round. Meanwhile, the team is relatively small, with just 7 full timers in their Long Beach, California HQ. Founder Kofi Asante co-founded Powerloop, which was acquired by Uber Freight, giving him deep insight into shipping and port operations that has helped in his new project. [He was our guest on TWiST back in August!] | Try it yourself at harmonic.ai | Subscribe to Us On Your Favorite Podcast Platforms | | | SF Live-Work Space Now Available | Need a flexible living and working environment in San Francisco? This thoughtfully designed loft-style residence at 787 Bryant St., the heart of the vibrant SOMA district and the city’s creative hub, is now available for rent or purchase. Check the listing for more details. | The TWiST500 newsletter is the new, updated, and improved TWiST Ticker. |
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