#AskJcal Request | Got a burning question for JCal? We want to hear it, and he might answer it on an upcoming episode of TWiST. Send us an audio or video clip of you asking the question. You can hit us up via DM or email your file to nils@launch.co. And be sure to include your name and a social media link so we can shout you out! (A little plug for your company is okay, too, but let’s not go nuts.) |
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| Top Stories | Fields medalist Jacob Tsimerman, who joins OpenAI later this month, launched the Mathematical AI Safety Institute to apply higher mathematics to controlling runaway AI. — The New York Times Australian lawmakers proposed a new regulation called “My Feed, My Way,” requiring social platforms to notify users and let them opt in or out of algorithmic recommendations. — ABC China said its AI computing capacity surged by 177% year over year to 2,185 exaflops by June, with $532B planned in IT infrastructure spending. — South China Morning Post Meta failed to catch 350 ads containing AI-generated child sexual abuse material, prompting lawmakers to plan an investigation. — Wired
| Top Funding Announcements | Decart AI — The chip-efficiency software startup’s proposed $6B acquisition by Anthropic fell apart after due diligence, though the companies may still explore other collaborations. — Bloomberg Forus — The healthcare automation startup raised a $150M Series C at a $3B valuation to expand its AI tools for speeding prescriptions through insurance. — Bloomberg Blee — The financial-services marketing compliance startup raised a $7M seed and $20M Series A led by Fin Capital and SMBC. — Axios Stoke Space — The reusable rocket startup completed the initial closing of a $1B Series E to reach orbit and prepare a larger rocket for operations. No lead investor was disclosed. — TechCrunch Mistral — The French AI developer raised a €3B Series D led by Samsung at a roughly €21B valuation. — Bloomberg
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| | | This Week in Startups |  | Dr. Mark Hyman on Function Health & GLP-1 microdosing | E2334 |
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| Timestamps: 0:00 What is a function, actually 6:01 Healthspan vs. sick care 9:34 Odoo - The all-in-one business platform. Your first app is free! Get started today at https://Odoo.com/twist 10:50 A $300 vitamin D test vs. a $10 one 17:26 Should a 25-year-old get a whole-body MRI? 20:00 Northwest Registered Agent - Got a new business idea? Northwest Registered Agent helps you bring it to life. Get a free domain, email, phone number, and more - with no purchase required! Learn more at https://www.northwestregisteredagent.... 23:41 Why is medicine still running on paper 24:59 The study where the chatbot beat the doctors 26:20 micro1, doctors in the loop, and why AI still needs guardrails 28:08 Wearables, records, and the CD-ROM problem 29:25 Rippling - Thanks to our partners at Rippling! Head to https://Rippling.ai/twist and get the only AI built to give you full visibility across your startup and take complex actions across your entire business. 32:09 The wearable that caught Jason's COVID 33:49 Alcohol, sugar, and why almost nobody tests your insulin 39:18 GLP-1s: Jason's 213-to-168 story 41:40 Microdosing GLP-1s, muscle loss, and "skinny fat" 48:06 Overdiagnosing mental illness: SSRIs, Adderall, and a lost decade 49:35 The biology underneath depression and anxiety 53:50 Psychedelics: ketamine, ibogaine, and the second revolution in psychiatry |
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| Today’s Fascinating Fact from Harmonic | Decart provides a GPU-optimization stack that squeezes more out of inference hardware, known as DOS. Other products include Oasis, an AI world model that generates fully interactive environments in real time, and Lucy, a live video-editing model that allows for real-time creative AI workflows. The company went from a valuation of just over $100M in October 2024 to $4 billion in May 2026, a 40x increase in under two years. It’s now Israeli’s first AI startup to cross a $1 billion valuation. | Try it yourself at harmonic.ai | Subscribe to Us On Your Favorite Podcast Platforms | | | SF Live-Work Space Now Available | Need a flexible living and working environment in San Francisco? This thoughtfully designed loft-style residence at 787 Bryant St., the heart of the vibrant SOMA district and the city’s creative hub, is now available for rent or purchase. Check the listing for more details. | The TWiST500 newsletter is the new, updated, and improved TWiST Ticker. |
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