Ver­tex Phar­ma­ceu­ti­cals is mak­ing the largest ac­qui­si­tion in its his­to­ry, beef­ing up its com­mer­cial port­fo­lio with a $10 bil­lion takeover of Cri­net­ics Phar­ma­ceu­ti­cals. The Boston drug­mak­er said Mon­day af­ter­noon it will buy Cri­net­ics...