A Halley’s Comet-level event in the world of subscriptions is occurring at Microsoft: the company announced it will lower the price of its Game Pass Ultimate from $29.99 to $22.99. But with the price drop, Game Pass is also getting nerfed — new “Call of Duty” titles will no longer be added to the service at launch, instead joining the library about a year later during the following holiday season.
The S&P 500, Russell 2000, and Nasdaq 100 closed lower on Tuesday. Stocks erased modest early gains and fell further on negative news reports about the status of peace talks between the US and Iran, which culminated in reports shortly before markets closed that Vice President Vance’s trip to Pakistan for those talks had been canceled. Postmarket, President Trump seemed to give the market some hope with a Truth Social post extending the ceasefire indefinitely.
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- Saturday, Trump signed an executive order that would expedite approvals of psychedelic substances to treat mental illness, specifically calling out ibogaine, a plant-derived substance used in other countries to treat post-traumatic stress disorder.
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Food and Drug Administration Commissioner Marty Makary said priority review vouchers, which allow for a fast-tracked review process, would be given to three psychedelic treatments this week. Shares of psychedelic biotechs — such as Psyence Biomedical, Compass Pathways, Definium Therapeutics, and GH Research — rallied on the news.
- Their treatments use psychedelic compounds derived from plants, mushrooms, and toads to treat a range of mental health conditions. The drugs are administered at specialized clinics where patients remain under observation for several hours after a dose is given.
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Companies developing psychedelic treatments face several hurdles, including the logistics of testing substances that are often considered dangerous drugs by the federal government, and at times an unfriendly FDA.
The FDA has already approved a form of ketamine (which is technically not considered a psychedelic, though that’s a subject of debate) for treatment-resistant depression, called Spravato, which is a nasal spray sold by Johnson & Johnson. It’s expected to sell $2 billion worth this year. The active compound is esketamine, a component of the anesthetic and party drug ketamine.
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- “As we kick off earnings for megacap tech stocks, this stood out: [hedge funds] have started buying Mag7 stocks again this month though positioning remains well below the peak levels seen in early 2016,” wrote Goldman Sachs’ Cullen Morgan.
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In early April, JPMorgan strategist Arun Jain noted that retail investors had basically been selling everything but the Magnificent 7 stocks as part of a more cautious stance due to the Iran war.
- Apple has been a long-standing exception to this trend, presumably because retail traders aren’t fond of its hands-off approach to AI.
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During Tim Cook’s 15-year tenure as CEO, he oversaw Apple stock gains of 1,933%, nearly quadrupling the S&P 500’s return in that time. When John Ternus takes over the role, Wall Street has some big expectations — as well as recommendations — for what he needs to do to “define his own path and the future success of Apple.”
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