addiction
How one overdose antidote went bust

Illustration: Camille MacMillin/STAT; Photo: Indivior via AP
Just two years ago, data indicated that Opvee was going to be a “best-in-class” medication to resuscitate people experiencing an overdose — more powerful than Narcan. But as STAT’s Lev Facher reports, there was one major problem: The people the drug was designed to help didn’t want it.
At first, people saw the medication as potentially unnecessary, especially given the severe withdrawal it could cause. Then, New York’s attorney general launched an investigation into the company’s sales tactics. Last fall, it stopped marketing the drug altogether. Read more from Lev on how the company failed, and why harm reduction advocates are logging a victory.
mental health
The factors contributing to adolescent depression
Two studies published yesterday investigated how certain exposures at home might affect young people’s mental health:
The first, published in JAMA Network Open, asked if exposure to lead during childhood was associated with mental health later on. More than 200 kids had their blood tested from age 1 to 12 for lead levels, which were connected with self- and parent-reported depression or anxiety symptoms at 12. Researchers found that higher blood lead concentrations correlated with more depressive symptoms, particularly for adolescents whose exposure to lead occurred later in childhood. The association was also more specific to behavioral symptoms of depression versus its cognitive-emotional dimensions. There were no similar associations with anxiety symptoms. The paper expands on previous research that measured lead levels just once.
In the New England Journal of Medicine, researchers analyzed how young people’s mental health changes after a parent suffers a firearm injury. Using commercial health insurance claims data, the researchers found that such injuries were associated with more than 8 additional psychiatric diagnoses per 1,000 young people (ages 1 to 19) compared to the control group, as well as 23 more mental health visits per 1,000 young people per year. There were no changes in rates of non-psychiatric diagnoses, medical encounters, or services.
first opinion
(A couple) questions for 2026, answered
Two First Opinion essays published today answer pertinent questions in today’s health care landscape:
What happens when you share your health information with ChatGPT Health? Liz Salmi, a patient-turned-researcher, turned her records over the tool. And she’s got plenty of records after being diagnosed with a malignant brain tumor nearly two decades ago. The biggest potential for ChatGPT Health, she writes, is how it can access recent data across different health systems. “Referrals come and go, and no single system holds my entire story — except my brain,” Salmi writes. “And now, partially, in these GPTs.” Read more on how the tool served her.
Do pediatricians get rich off vaccines? Three scientists — including, yes, two pediatricians — conducted a six-month investigation into this question. The short answer? “No.” The long answer? “The truth is far more complicated than the false profit narrative suggests.” Read more about the messy economics, what the profit narrative misses, and what we should actually be worried about.