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17 November, 2025
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1. Novo Nordisk lowers self-pay prices for weight loss drugs ahead of Lilly, TrumpRx
2. Drugmakers say HHS' 340B pilot is limited as they fight for their own rebate models
3. New US trade deal caps Switzerland, Liechtenstein pharma tariffs at 15%
4. Despite getting a CRL, Scholar Rock expects to launch spinal muscular atrophy drug next year
5. Zymeworks and Jazz tout HER2 bispecific success in first Phase 3 readout
6. Jeffrey Bluestone hands Sonoma CEO post to Stephen Dilly
7. Lilly makes up to $2.6B pact with South Korean biotech
8. Genmab cans another ADC from ProfoundBio deal in area of J&J's Ambrx buyout
9. Nuvalent shares Phase 1/2 data for ALK inhibitor that could battle with Pfizer’s Lorbrena
10. Five takeaways after Merck's $9.2B Cidara deal: More M&A, 'diversified' growth, shifting production to the US
11. J&J to buy Halda for $3.05B, adding startup's RIPTAC cancer drug
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Alexis Kramer
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The Supreme Court said today it won’t review the FDA’s denial of fast-track status for Vanda Pharmaceuticals’ tradipitant in a chronic stomach condition called gastroparesis. Last month, the company had agreed to pause separate, administrative proceedings over its application for gastroparesis until Jan. 7. Meanwhile, the FDA is reviewing the experimental drug for the treatment of motion sickness, with a decision date of Dec. 30.

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Alexis Kramer
Editor, Endpoints News
Maziar Mike Doustdar, Novo Nordisk CEO (Nichlas Pollier/Bloomberg via Getty Images)
1
by Zachary Brennan

No­vo Nordisk said Mon­day it will im­me­di­ate­ly drop its cash-pay prices for megablock­busters Ozem­pic and We­govy to $349 per month, more than six weeks be­fore Eli Lil­ly’s ri­val weight loss drug Zep­bound is ex­pect­ed to match that price.

The move is the lat­est jab by No­vo in a long-run­ning com­pe­ti­tion be­tween the two com­pa­nies and drug com­pounders. Both No­vo and Lil­ly pledged the near­ly $150 month­ly re­duc­tion for cash-pay­ing pa­tients as part of deals made with the Trump ad­min­is­tra­tion ear­li­er this month, with dis­counts made in ex­change for Medicare cov­er­age.

The cash price of both GLP-1 mak­ers’ in­jecta­bles will be low­ered to $250 per month in two years, ac­cord­ing to the Trump ad­min­is­tra­tion. Month­ly sup­plies of the tablet ver­sions, if ap­proved by the FDA, will be sold for $150 on the White House­'s in­com­ing on­line phar­ma­cy TrumpRx, which is ex­pect­ed to launch ear­ly next year.

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2
by Nicole DeFeudis

Coun­sel for Eli Lil­ly, No­var­tis and Bris­tol My­ers Squibb told a pan­el of judges that the gov­ern­ment’s re­bate pi­lot pro­gram is too lim­it­ed in scope to ad­dress drug­mak­ers’ broad­er con­cerns with the 340B sys­tem.

HH­S' Health Re­sources and Ser­vices Ad­min­is­tra­tion re­cent­ly ap­proved ap­pli­ca­tions from nine drug­mak­ers to par­tic­i­pate in a pi­lot that would sig­nif­i­cant­ly change the way the 340B dis­count pro­gram op­er­ates. For now, it on­ly ap­plies to the 10 drugs that were sub­ject to the first round of Medicare ne­go­ti­a­tions un­der the In­fla­tion Re­duc­tion Act.

“The prob­lem with the pi­lot pro­gram, of course, is it on­ly ap­plies to man­u­fac­tur­ers whose drugs have been cho­sen for drug price ne­go­ti­a­tion and on­ly to those drugs,” Cather­ine Stet­son, a Hogan Lovells at­tor­ney rep­re­sent­ing the three drug­mak­ers, said dur­ing a Mon­day oral ar­gu­ment be­fore the US Court of Ap­peals for the DC Cir­cuit.

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3
by Anna Brown

Tar­iffs on brand­ed phar­ma­ceu­ti­cal prod­ucts from Switzer­land and Liecht­en­stein will be capped at 15% un­der a new trade deal with the US, the White House an­nounced.

The US will ap­ply whichev­er is high­est out of the "most fa­vored na­tion" (MFN) tar­iff rate or a 15% tax on goods orig­i­nat­ing from the two coun­tries, the Trump ad­min­is­tra­tion said on Fri­day. These levies will not ex­ceed 15% for any prod­ucts that are sub­ject to fu­ture phar­ma tar­iffs aris­ing from the De­part­ment of Com­merce's Sec­tion 232 in­ves­ti­ga­tion.

This lat­est deal mir­rors the de­tails of the US-EU deal an­nounced in Ju­ly and re­flects the Trump ad­min­is­tra­tion's goal of boost­ing drug man­u­fac­tur­ing in the US, with over $480 bil­lion pledged to the coun­try so far this year.

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