You may not have heard of Simonetta Cattaneo Vespucci, but you’ll know her from Botticelli’s The Birth of Venus and Primavera, where she appears as both Venus and Flora. Botticelli was obsessed with Simonetta and requested that he be buried at her feet when he died.

Sadly, she died decades before Botticelli, at the tender age of 23. Art historians have long believed that consumption – or what we today call tuberculosis – was what killed her. In a new paper, endocrinologist Paolo Pozzilli, puts forward a different theory. Several pieces of evidence, he says, suggest that Simonetta had a pituitary tumour.

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