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White House, AstraZeneca expected to announce drug price deal Read in browser
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1. Biosecure is back. It doesn't appear as threatening to biotechs as before
2. J&J is in discussions to buy out Protagonist Therapeutics — report
3. White House, AstraZeneca expected to announce drug price deal
4. Head of FDA's orphan drug office is removed from role
5. Person previously ineligible for gene therapy granted treatment after antibody-chopping drug clears the way
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Alexis Kramer
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President Donald Trump later today is expected to announce a second "most favored nation" drug pricing deal, this time with AstraZeneca. Trump announced a deal with Pfizer just last week. Stay tuned for more after 5 p.m. ET!

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Alexis Kramer
Editor, Endpoints News
1
by Jared Whitlock

The Biose­cure Act has an­oth­er chance in Con­gress af­ter the Sen­ate passed a new ver­sion this week. But the lat­est it­er­a­tion stops short of tar­get­ing WuXi AppTec and WuXi Bi­o­log­ics, key fix­tures in US drug­mak­ers’ sup­ply chains.

The Sen­ate vot­ed on Thurs­day to at­tach Biose­cure as an amend­ment to the an­nu­al de­fense pol­i­cy bill. It seeks to curb US biotechs’ re­liance on Chi­nese sup­pli­ers over na­tion­al se­cu­ri­ty con­cerns.

Un­like last year’s pro­pos­al, which ex­plic­it­ly named the WuXi com­pa­nies and oth­ers in Chi­na, the re­vised bill lim­its its scope to com­pa­nies tied to Chi­na’s mil­i­tary based on ex­ist­ing gov­ern­ment watch lists. Those in­clude BGI Group and MGI Tech, but not the WuXi en­ti­ties.

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2
by Max Gelman

John­son & John­son is re­port­ed­ly in talks to ac­quire a part­ner that’s de­vel­op­ing a linch­pin of its fu­ture im­munol­o­gy plans.

J&J and Pro­tag­o­nist Ther­a­peu­tics are in dis­cus­sions for a buy­out, the Wall Street Jour­nal re­port­ed Fri­day, cit­ing peo­ple fa­mil­iar with the mat­ter. The ex­act pa­ra­me­ters of the deal were not dis­closed, and it’s not cer­tain that a deal will take place.

Pro­tag­o­nist’s stock PT­GX surged Fri­day morn­ing by more than 35%, ris­ing above $90 per share for the first time in the com­pa­ny’s his­to­ry. As of Thurs­day’s mar­ket close, Pro­tag­o­nist had a mar­ket cap of $4.06 bil­lion.

A spokesper­son for Pro­tag­o­nist told End­points News in an email that the com­pa­ny “doesn’t com­ment on spec­u­la­tion or ru­mor.” A J&J spokesper­son didn’t im­me­di­ate­ly re­spond to a re­quest for com­ment.

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Pascal Soriot, AstraZeneca CEO (Justin Tallis/Press Association via AP Images)
3
by Max Bayer

The White House and As­traZeneca are ex­pect­ed to an­nounce a deal on drug pric­ing lat­er Fri­day, ac­cord­ing to peo­ple fa­mil­iar with the mat­ter, as Pres­i­dent Don­ald Trump strikes a sec­ond agree­ment un­der his "most fa­vored na­tion" push.

A White House of­fi­cial con­firmed to End­points News that there would be a drug price an­nounce­ment around 5 p.m. ET Fri­day, but de­clined to say which com­pa­ny or com­pa­nies would be there, if any. Ru­mors of As­traZeneca's deal were cours­ing through Wash­ing­ton Fri­day, as the in­dus­try spec­u­lat­ed about who would an­nounce next.

An As­traZeneca spokesper­son de­clined to com­ment. On Thurs­day, the com­pa­ny's CEO Pas­cal So­ri­ot and Vir­ginia Gov­er­nor Glenn Youngkin broke ground on a $4.5 bil­lion in­vest­ment on a new man­u­fac­tur­ing site. The com­pa­ny has pledged $50 bil­lion in new in­vest­ment in the US.

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4
by Max Bayer

The head of the FDA of­fice that helps de­ter­mine or­phan drug des­ig­na­tions has been re­as­signed and is no longer in the role, an ad­min­is­tra­tion of­fi­cial con­firmed to End­points News.

San­dra Ret­zky, di­rec­tor of the Of­fice of Or­phan Prod­ucts De­vel­op­ment, is no longer in the role but she has not been fired, the source told End­points on Fri­day. It was­n't clear to where Ret­zky was re­as­signed, and she did­n't re­spond to mul­ti­ple at­tempts to reach her for com­ment.

The or­phan drug job sits with­in the of­fice of the FDA's chief med­ical of­fi&s