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9 July, 2025
IS CHINA A THREAT, OR AN INVESTMENT OPPORTUNITY?
This week on Post-Hoc Live: As more biopharmas turn to China for deals, Curie.Bio CEO Zach Weinberg joins us to break down the risks, rewards and what investors should do next.
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Un­cov­er­ing the Po­ten­tial of Tar­get­ing the CD38 Path­way for Im­mune-Me­di­at­ed Dis­eases
top stories
1. Who pays the most in biopharma? We analyzed median pay at 177 companies
2. Updated: Merck drops $10B for respiratory drugmaker Verona Pharma in its first acquisition of 2025
3. Revolution and Iambic to combine data and AI models in R&D deal for cancer drugs
4. Rhythm says oral rare obesity drug clears Phase 2 test, plans tweaks to formulation
5. Trump’s CDC nominee Monarez advances to full Senate
6.
news briefing
Novartis' brain delivery platform option deal worth up to $175M; Neumora's next steps
7. FDA approves new dosing of Lilly’s Alzheimer’s drug to lower brain swelling risks
8. Nimble radiopharma biotech Actithera gets $75M to enter the clinic
9. AstraZeneca’s Alexion inks AAV capsid deal with JCR Pharma
10. Supreme Court halts California order that blocked RFK Jr. from reorganizing HHS
more stories
 
Reynald Castaneda
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In part two of Endpoints' look at biopharma pay packages, Andrew Dunn went through hundreds of documents to look at companies’ median pay for their workers. Click here to find out which ones made it into the top 20.

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Reynald Castaneda
Deputy Editor, Endpoints News
1
by Andrew Dunn

The typ­i­cal em­ploy­ee at a pub­licly trad­ed life sci­ences com­pa­ny made $224,729 last year, ac­cord­ing to an End­points News analy­sis of pay trends across the in­dus­try.

End­points re­viewed hun­dreds of an­nu­al proxy fil­ings, find­ing 177 bio­phar­mas that dis­closed me­di­an pay for their work­force. The me­di­an across those re­port­ing com­pa­nies was $224,729, a 13% in­crease from $199,048 in 2023. Even with the biotech mar­ket set­tling in­to the fourth year of a down­turn, the da­ta show re­main­ing em­ploy­ees are ex­tra­or­di­nar­i­ly well-paid. The typ­i­cal drug in­dus­try work­er made more than five times the me­di­an Amer­i­can’s in­come of $42,220.

There are lim­its to the com­par­i­son, though, as End­points’ analy­sis on­ly in­cludes pub­licly trad­ed com­pa­nies that are re­quired to dis­close this pay in­for­ma­tion. This doesn’t in­clude the vast ma­jor­i­ty of for­eign-fil­ing com­pa­nies, as well as many small­er biotechs that are ex­empt from dis­clos­ing me­di­an pay.

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2
by Kyle LaHucik

Mer­ck is boost­ing its res­pi­ra­to­ry port­fo­lio with a $10 bil­lion takeover of com­mer­cial-stage drug­mak­er Verona Phar­ma, the com­pa­nies said Wednes­day morn­ing.

It sig­nals Mer­ck’s on­go­ing ap­petite for large deals to gain ac­cess to near-term sales, but al­so to pad its fu­ture rev­enue stream as the world’s top-sell­ing drug, the can­cer med­i­cine Keytru­da, comes off patent lat­er this decade. It’s the in­dus­try’s sec­ond-largest deal this year, be­hind John­son & John­son’s $14.6 bil­lion pur­chase of In­tra-Cel­lu­lar in Jan­u­ary.

The New Jer­sey phar­ma gi­ant is buy­ing in­to a fresh­ly com­mer­cial com­pa­ny. Verona snagged FDA ap­proval for Ohtu­vayre 13 months ago. The drug is ap­proved as a main­te­nance treat­ment for adults with chron­ic ob­struc­tive pul­monary dis­ease, or COPD. The North Car­oli­na and Lon­don biotech is al­so test­ing the in­haled med­i­cine for non-cys­tic fi­bro­sis bronchiec­ta­sis.

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3
by Andrew Dunn

Rev­o­lu­tion Med­i­cines has be­come one of the in­dus­try's most valu­able pre-com­mer­cial com­pa­nies thanks to its pipeline of clin­i­cal-stage can­cer drugs. CEO Mark Gold­smith is press­ing ahead on what could be next by sign­ing a new re­search deal with a lead­ing AI-fo­cused biotech.

Rev­o­lu­tion will pair its unique li­brary of mol­e­c­u­lar struc­tures and da­ta with the AI mod­els de­vel­oped by Iambic Ther­a­peu­tics, the two biotechs an­nounced Wednes­day. Rev­o­lu­tion will pay $25 mil­lion in the short term to Iambic through a mix of up­front pay­ments and near-term mile­stones.

Most R&D part­ner­ships are struc­tured around ad­vanc­ing spe­cif­ic mol­e­cules. This deal fo­cus­es more on AI and da­ta than on de­liv­er­ing com­pounds. Iambic will train a cus­tomized ver­sion of Neu­ralPLex­er, its AI mod­el that pre­dicts bio­mol­e­c­u­lar struc­tures, on Rev­o­lu­tion's da­ta.

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Manufacturing Day 2025
What are the new rules for biopharma manufacturing? The Trump administration’s tariff policies have thrown the world economic order off its axis, and manufacturing is squarely in the middle of the upheaval. Join us as we break down what’s really happening behind the scenes — get your spot.
4
by Ayisha Sharma

Rhythm Phar­ma­ceu­ti­cals said Wednes­day its oral can­di­date for a rare form of obe­si­ty pro­duced “sta­tis­ti­cal­ly sig­nif­i­cant and clin­i­cal­ly mean­ing­ful” re­duc­tions in BMI in a mid-stage tri­al.

The biotech al­so said that it is fine-tun­ing the for­mu­la­tion of its MCR4 ag­o­nist, dubbed bi­vame­lagon, ahead of a Phase 3 pro­gram with an eye on im­prov­ing its tol­er­a­bil­i­ty.

The drug is be­ing in­ves­ti­gat­ed for ac­quired hy­po­thal­a­m­ic obe­si­